There's a lot to said for flying out to Dayton. It sure is fast and convenient and if you are traveling by yourself it may be the best way to go.
But, if you'd like to have a lot of fun and you enjoy driving you can stop and see things along the way. You can form a convoy and chat on the radio, that's a blast.
On a couple of years where the Kids club convoyed to Dayton we used window paint and wrote out our names and call signs on the windows of our cars along with our convoy simplex frequency. Other hams on the road seeing our frequency and hearing our chatter would join in and chat with us. On our way home one year we met a carload of fellow hams that were heading home to New York and we stopped at the Cracker Barrel on our way out of Ohio and had supper with them.
Something that my boys and I like to do too is stop in the Wheeling area and shop at the huge Cabela's store there. If you know what Bass Pro is you have some small idea of what Cabela's is. Cabelas's is larger and more diversified than Bass Pro. It's more of an outfitter whereas Bass Pro specializes mor in hunting and fishing. You think that "big" tank at the Bass Pro in Hanover is a big aquarium? The smallest aquarium at a Cabela's is bigger and they have running artificial streams in the stores stocked with fish and you can feed them. The full standing animal mounts are fantastic.
The Wheeling Cabela's at 175,000 sq. ft. is not their largest store but it's complete. Cabela's has a 250,000 sq. ft. store in Hamburg, PA.
If you like camping and outdoors stuff it's worth driving just so you can stop at the Cabela's. http://www.cabelas.com/
Dayton traveling to/from
If you have time save the toll of the PA Turnpike and take I68. Another interesting stop just west of Hancock, MD is the Sideling Hill cut. Here you can see the geology laid naked for all to see. Checkout the rock strata and the visitors center. The wildly convoluted lines of the strata were caused by the pressures of the push of the Mid-Atlantic Ridge against the North American Plate. The visitors center is at the base of the cut, and a protected path offers access to partway up the North side of the cut for a closer view of the rock layers.
Very impressive. Again if you have the time it's worth stopping and it's a good place to take a break in the driving.